Part 1: Morphological aspects of liver regeneration Krzysztof A. Bardadin, Barbara Łukomska Medical Science Review - Hepatologia 2005; 5 22-30 aaICID: 16109
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Zakład Patomorfologii Centrum Medycznego Kształcenia Podyplomowego w Warszawie Zakład Neurobiologii Naprawczej Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polskiej Akademii Nauk, Warszawa
Liver regeneration is well known phenomenon occurred after partial hepatectomy either in experimental animals or humans. The current concept of liver regeneration can be modeled as at least a three-tier system of cell replacement. First, based on hypertrophy and mitoses within hepatocytes is called adaptation. However, senescence of the liver cells based on telomere shortening might reduce regenerative capacity greatly. Second, based on the concept of intra-organ stem cell compartment, located mostly, if not entirely, in the smallest, most proximal branches of biliary tree, i.e. canals of Hering and the intralobular bile ducts. Third tier of liver cell replacement has recently been identified, consisting of cells entering the liver from circulation. This cell compartment, probably of bone marrow origin enter the liver, when there is marked injury and repopulate intra-stem cell compartment or fuse with hepatocytes for a new population of hepatocytes. There is also growing evidences, that also endothelial and stellate/myofibroblastic cells could originate from bone marrow precursors in pathological conditions.