XV Konferencja Naukowa Polskiego Towarzystwa Hepatologicznego
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Part 2: Pathomechanisms of liver regeneration
Barbara Łukomska, Joanna Dłużniewska, Krzysztof A. Bardadin
Medical Science Review - Hepatologia 2005; 5 31-40
aaICID: 16110
IC™ Value: 1.86
Abstract provided by Publisher
 
Zakład Neuropatologii Naprawczej, Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polska Akademia Nauk, Warszawa
Pracownia Biologii Molekularnej Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polska Akademia Nauk, Warszawa
Zakład Patomorfologii Centrum Medycznego Kształcenia Podyplomowego, Warszawa

The liver is unique in that it responds to physical or chemical injury by the process of regeneration. Thus hepatic regeneration is defined as an complex response induced by specific external stimuli and involving sequential changes in gene expression, growth factor production and morphologic structure. Many growth factors and cytokines i.e. hepatocyte growth factor (HGF), transforming growth factor a (TGF-a), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), interleukin 6 (IL-6), tumor necrosis factor a (TNF-a), insulin, noradrenalin appear to play important roles in this process. The recent studies have brought a better understanding of the molecular mechanisms of hepatic growth control. However, many questions still remain unanswered.

ICID 16110


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