Acute liver failure in children Irena Jankowska, Jerzy Socha Medical Science Review - Hepatologia 2005; 5 48-56 aaICID: 16112
Article type: Original article
IC™ Value: 3.71
Abstract provided by Publisher
Klinika Gastroenterologii, Hepatologii i Immunologii Instytutu „Pomnik – Centrum Zdrowia Dziecka” w Warszawie
Acute liver failure in childhood is a rare but often fatal disorder with very high mortality without transplantation. It etiology depends on age and includes in neonates period infections, metabolic disorders, whereas autoimmune hepatitis or drug/ toxins induced liver failure is most common in older children. In some cases etiology remains unknown. The clinical presentation includes coagulopathy and jaundice but encephalopathy can be a late event or may not develop at all (in contrast to adults). Universally accepted criteria for listing for liver transplantation have not been defined in children. Liver transplantation has markedly improved the prognosis of children with acute liver failure.