Liver damage in patients on long-term parenteral nutrition Małgorzata Łyszkowska, Janusz Książyk Medical Science Review - Hepatologia 2005; 5 76-79 aaICID: 16116
Article type: Review article
IC™ Value: 2.97
Abstract provided by Publisher
Klinika Pediatrii, Oddział Żywienia Instytut „Pomnik – Centrum Zdrowia Dziecka”, Warszawa
Long-term parenteral nutrition is the only one life-saving treatment of the patients with gut failure. Hepatic alteration, as manifested by increased enzyme activity and increased bilirubin level is observed in patients on long-term parenteral nutrition. In majority of patients the enzymes are elevated to minor degree. It is often reversible phenomenon, but in some it leads to liver failure. Steatosis, steatohepatitis and cholestasis are the most common metabolic complications which may occurre in patients on long-term parenteral nutrition. The most important factors responsible for liver damage related to parenteral nutrition are: excess of caloric intake, excess of ferrous intake, duration and the method of parenteral nutrition administration. Other important factors are related to primary disease, its complications, gut failure (length of remaining part of bowel, bacterial overgrowth caused by gut obstruction or stasis, lack of ileocaecal valve), hepatotoxic medicines, concomitant general or abdominal infections, viral hepatitis, pathologies of bile ducts, metabolic diseases and inability for enteral nutrition.