XV Konferencja Naukowa Polskiego Towarzystwa Hepatologicznego
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Journal Abstract
 
Hematological abnormalities in Budd-Chiari
MaƂgorzata Rokicka
Medical Science Review - Hepatologia 2005; 5 80-84
aaICID: 16117
IC™ Value: 1.86
Abstract provided by Publisher
 
Klinika Hematologii, Onkologii i Chorób Wewnętrznych AM w Warszawie

The thrombophilic state like myeloproliferative disorders and thromophilia should be excluded in any case of Budd-Chiari syndrome.
Hepatic vein thrombosis is caused by one or several thrombogenic conditions of which myeloproliferative disorders are the most frequent. Erythroid colony formation in absence of erythropoietin is reliable indicator of a primary myeloproliferative disoder. The overexpression of PRV – 1 seems to be a useful tool in future for discriminating ET and PV from different myeloproliferative disorders. The cytoreductive treatment is necessary in this condition after the surgery procedures.
Other implicated etiologies include thrombophilia states. Factor V Leiden is the most important inherited risk factor of venous thrombosis. In this condition the activated form of factor V is resistant to the cleavage by protein C. Factor V Leiden prolongs coagulation activity for an extended period, resulting in thrombophilia. The inherited deficiencies of antithrombin III, protein C and protein S must be also excluded. The anticoagulant therapy is indicated
The thrombophilic state like myeloproliferative disorders and thromophilia should be excluded in any case of Budd-Chiari syndrome.

ICID 16117


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