Acute liver failure in adults Robert Flisiak Medical Science Review - Hepatologia 2006; 6 31-33 aaICID: 449229
Article type: Original article
IC™ Value: 3.59
Abstract provided by Publisher
Acute liver failure (ALF) is life-threatening condition with rapid development of encephalopathy and coagulopathy in patients without previous chronic liver disease. Additional infections and multiorgan insufficiency can also be part of the ALF picture. Accompanying cerebral edema is a very dangerous condition that is usually difficult to manage. Depending of the region, the most frequent causes of ALF are acetaminophen poisoning and HBV infection. Additional etiologies of ALF include drug-induced idiosyncratic hepatotoxicity, HAV or HEV infections, mushroom poisoning, autoimmune hepatitis, Wilson’s disease, and Budd-Chiari syndrome. ALF therapy should be related to etiology, but in severe clinical forms the treatment is nonspecific and should be focused on preventing cerebral edema, hepatic encephalopathy, and gastrointestinal bleeding. Failure of conservative treatment and high risk of death should be indications for possible liver transplantation.