XV Konferencja Naukowa Polskiego Towarzystwa Hepatologicznego
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Problems associated with bacterial infections and use of antibiotics in patients with liver cirrhosis
Marek Hartleb
Medical Science Review - Hepatologia 2006; 6 55-60
aaICID: 449244
Article type: Original article
IC™ Value: 3.59
Abstract provided by Publisher
Bacterial infections are common and severe complications of cirrhosis. They are responsible for up to 25% of deaths among cirrhotic patients. The most frequently recognized infections include spontaneous bacterial peritonitis, urinary and respiratory tract infections, and bacteremia. The high frequency of bacterial infections in decompensated cirrhosis results from various facilitating mechanisms, such as changes in the reticuloendothelial system, decreased opsonic activity of the ascitic fluid, neutrophil leukocyte dysfunction, increased bacterial translocation from the gut, and iatrogenic factors. Rapid inclusion of the proper antibiotic is the only way to cure infection; however, in some cases antibiotics may show toxic properties, leading to a worsening of clinical outcome. The third-generation cephalosporins are currently advocated for the treatment of severe infections in cirrhotic patients because of their high activity against the most commonly encountered pathogens (Escherichia coli and Streptococcus pneumoniae) and relative safety for the liver

ICID 449244

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