Fungal septic complications in hepatology Jadwiga Mészáros, Monika Bieniasz Medical Science Review - Hepatologia 2006; 6 61-64 aaICID: 449245
Article type: Original article
IC™ Value: 3.59
Abstract provided by Publisher
Invasive fungal infections have emerged as major causes of morbidity and mortality in immunocompromised patients. In hepatological septic complications they are related primarily to bacterial infections. Cholangitis, intra-abdominal abscesses, septic fistula, and peritonitis develop after liver surgery or transplantation. Besides their increasing frequency, invasive fungal infections are still associated with high mortality in bloodstream infections caused by Candida species and over 70% in invasive Aspergillosis. Several factors, including difficulties in diagnosing a deep mycosis, impaired immunity of the patient, and the treatment failure rate, contribute to the poor prognosis of invasive fungal septic complications. Currently, three classes of antifungals are used in the treatment of systemic fungal infections, including new azoles (voriconazole and posaconazole), lipid formulations of amphotericin B, and new drugs such as caspofungin and micafungin. The choice of antibiotics for treatment, based on activity, toxicity, pharmacokinetics, and efficacy, is reviewed.