Silymarin in treatment of liver diseases Napoleon Waszkiewicz, Sławomir D. Szajda, Magdalena Waszkiewicz, Małgorzata Knaś, Małgorzata Borzym-Kluczyk, Jacek Dobryniewski, Ewa Dutkiewicz, Piotr Zwierz, Krzysztof Zwierz Medical Science Review - Hepatologia 2006; 6 92-98 aaICID: 449256
Article type: Original article
IC™ Value: 3.59
Abstract provided by Publisher
Silymarin, the active component of milk thistle (Silybum marianum), is a mixture of the flavonoids silybin, silychristin, and silydianin. Silybin is the most prevalent of the three flavonoids and the most biologically active. Silymarin has multiple hepatoprotective mechanisms of action: antioxidant activity, anti-inflammatory effect, toxin blockade, protein synthesis, and antifibrotic activity. Silymarin was once used in the treatment of varicose veins, menstrual difficulty, and damage to the liver, spleen, and kidneys. It is currently prescribed as a therapeutic and hepatoprotective agent, especially in the treatment of toxin exposure, cirrhosis, and chronic hepatitis.