Biochemical basis of hepatic encephalopathy Małgorzata Knaś, Ewa Dutkiewicz, Małgorzata Borzym-Kluczyk, Krzysztof Zwierz Medical Science Review - Hepatologia 2007; 7 99-103 aaICID: 486004
Article type: Review article
IC™ Value: 2.88
Abstract provided by Publisher
Hepatic encephalopathy is disturbance of brain function, caused by failure of
hepatic clearance of gut-derived neurotoxins, false neurotransmitters and neuromodulators. In hepatic encephalopathy portal blood omits whole liver or only hepatocytes. Failure of hepatic clearance increases concentration in blood and cerebrospinal fluid: neurotoxins (mainly ammonia), amino acids (particularly aromatic: tyrosine, phenylalanine, tryptophan) which
are substrates for true and false neurotransmitters, and modulatory peptides. However none of three main suspects (ammonia, aromatic amino acids, and peptides ) can be condemned for solitary causing hepatic encephalopathy, as not all cases of hepatic encephalopathy proceeded with hyperammonemia, as well as increase in concentration of true and false neurotransmitters
and modulators, in blood and cerebrospinal fluid.