Apoptosis in selected liver diseases – clinical and therapeutic implications Sylwia Serafińska, Krzysztof Simon Medical Science Review - Hepatologia 2007; 7 104-110 aaICID: 486005
Article type: Review article
IC™ Value: 2.88
Abstract provided by Publisher
The liver is continuously exposed to a large antigenic load that includes pathogens, toxins, tumor cells and dietary antigens. Amongst the hepatitis viruses, only hepatitis B virus (HBV) and hepatitis C virus (HCV) cause chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma. Of the different antiviral defence systems employed by tissue, apoptosis significantly contributes to the prevention of viral replication, dissemination, and persistance. In addition apoptotic processes play a significant role both in liver damage and in the course of others liver disaeses (alkoholic hepatitis, hepatocarcinoma, cholangiocarcinoma, cholestatic disease, Wilson’s disease, autoimmunologic diseases). The assesment of the severity of liver disease, as well as monitoring of patients with chronic liver disease, remains
a major challenge in clinical hepatology practice. Therefore the development of new therapeutic strategies by protecting hepatocytes from apoptosis or by the induction of apoptosis in stellate cells remains very important resarch for the near future.