Macro-AST as a cause of elevated activity of serum aspartate aminotransferase Dariusz Marek Lebensztejn, Anna Romanowska Medical Science Review - Hepatologia 2008; 8 33-35 aaICID: 862333
Article type: Review article
IC™ Value: 3.01
Abstract provided by Publisher
Macroenzymes are enzymes in serum that have formed high-molecular mass complex, either by self-polymerization or by association with other serum components (mainly immunoglobulins and lipids). The frequency of macro-AST is low and it has benign evolution. Although the majority of macro-AST cases have been described in asymptomatic individuals, a number of cases have been described in association with hepatitis, inflammatory bovel disease and other autoimmune diseases, hepatic and other malignancies and after specific allergen immunotherapy. We review the literature on the diagnosis and clinical significance of macro-AST in adults and children.