XV Konferencja Naukowa Polskiego Towarzystwa Hepatologicznego
News
Current issue
Archival Issues
Search
Newsletter
Manuscript Submission
 » 
Journal Abstract
 
ß-hexosaminidase in liver diseases
Sławomir Dariusz Szajda, Alina Kępka, Napoleon Waszkiewicz, Jadwiga Snarska, Beata Zalewska-Szajda, Magdalena Waszkiewicz, Małgorzata Borzym-Kluczyk, Anna Jankowska, Joanna Jakimowicz-Rudy, Sylwia Chojnowska, Danuta Dudzik, Jacek Dobryniewski, Małgorzata Knaś, Ewa Dutkiewicz, Anna Stypułkowska, Agnieszka Zaniewska, Katarzyna Raczkowska, Justyna Marciniak, Marta Bruczko, Maciej Sadowski, Krzysztof Zwierz
Medical Science Review - Hepatologia 2008; 8 36-43
aaICID: 862334
Article type: Review article
IC™ Value: 3.01
Abstract provided by Publisher
 
Activity of N-acetyl-ß-hexosaminidase (HEX) in serum and urine may be a marker of liver disease. HEX is the lysosomal exoglycosidase which releases N-acetylglucosamine and N-acetylgalactosamine from non-reducing ends of oligosaccharide chains of glycoproteins, glycolipids and proteoglycans. Isoenzymes HEX A and HEX B have different structure, sensitivity for heating and neuraminidase treatment, as well as mobility in electric field. Activity of HEX and its isoenzymes in serum may be a marker for detection and monitoring of autoimmune hepatitis, autoimmune hepatitis with accompanying cholestasis and primary biliary cirrhosis. Activation of hepatocytes increases activity of HEX, transaminases and concentration of cholestastis indicators in serum, but activation of the Kupfer cells increases activity of lysosomal enzymes, mainly HEX. Acute and chronic damage to hepatocytes by alcohol and its metabolites increases HEX activity in serum and urine.

ICID 862334
 
FULL TEXT 364 KB


Related articles
  • in IndexCopernicus™
         alcoholic disease [1 related records]
         primary biliary cirrhosis [17 related records]
         autoimmune hepatitis with cholestasis [2 related records]
         autoimmune hepatitis [28 related records]
         N-acetyl-ß-hexosaminidase (HEX) [1 related records]


  •  

    Copyright © Medical Science Review - Hepatologia  2017
    Page created by Index Copernicus Ltd. All Rights reserved.