Hypoxic liver injury Danuta Dudzik, Małgorzata Knaś, Róża Wiśniewska, Małgorzata Borzym-Kluczyk, Krzysztof Raczkowski, Marek Niczyporuk, Alina Kępka, Ewa Dutkiewicz, Katarzyna Knaś-Karaszewska, Sławomir Szajda, Maciej Sadowski, Joanna Jakimowicz-Rudy, Krzysztof Zwierz Medical Science Review - Hepatologia 2008; 8 44-47 aaICID: 862335
Article type: Review article
IC™ Value: 3.01
Abstract provided by Publisher
Hypoxic liver injury (HLI), also known as hypoxic hepatitis, is due to inadequate oxygen uptake by the centrilobular hepatocytes, resulting in apoposis or necrosis. The pathophysiology of hepatic ischemia includes a decrease in ATP production and increase in activity of intra- and extracellular proteases. Hypoxia inducible factor (HIF-1) adapts liver cells to hypoxia by increase in expression of glycolytic enzymes, glucose transporters and proteins responsible for long life span of the liver cells. HIF-1 also increases expression of factors stimulating maturation of erythrocytes and angiogenesis. Hypoxia influence on many organs, including heart muscle and skin.