Inflammatory myofibroblastic tumor – one or more different diseases? Krzysztof A. Bardadin Medical Science Review - Hepatologia 2008; 8 100-105 aaICID: 862371
Article type: Review article
IC™ Value: 3.01
Abstract provided by Publisher
Inflammatory myofibroblastic tumor (IMT) or inflammatory pseudotumor (IP) has been discussed in details worldwide as primary tumor of the lung and upper respiratory tract. Histologically, IMT is characterized by a proliferation of spindle cells admixed with variable aounts of lymphoplasmacytic infiltrate. However, reporting of cases involving liver and biliary tree has increased over recent years some of them as a Klatskin’s tumor. The terms IMT sug-gested by World Health Organization in recent classification of soft tissue tumors probably cover many various tumors which have common only one feature-inflammatory infiltrate of neoplastic tissue. There are more immunohistochemical evidences, that some of them are in fact follicular dendritic reticulum cell tumor (FDRcT) usually connected with Epstein-Barr infection. There are also cases of IMT with expression of Anaplastic Lymphoma Kinase (ALK-1) expression. Recently, association with sclerosing cholangitis, especially IgG4-related variant and/or autoimmune pancreatitis was also described. The present review describe pathological aspect of this heterogenous group of tumors.