The guidelines for autoimmune hepatitis therapy in children treated in Children’s Health Memorial Institute Małgorzata Woźniak, Marek Woynarowski, Jerzy Socha Medical Science Review - Hepatologia 2009; 9 12-18 aaICID: 902236
Article type: Review article
IC™ Value: 3.04
Abstract provided by Publisher
Autoimune hepatitis (AIH) is an orphan disease. The limited epidemiological data show that the incidence of AIH in Poland is around 1/100,000 children and adolescents. Most patients are treated in hepatology referral centers. A survey conducted in 2007 showed that these centers differ in various aspects of their diagnostic and therapeutic approach to patients with AIH. This survey indicated the need to introduce a common standard for AIH diagnosis and therapy in children. This paper presents the standard approach to pediatric patients with AIH developed at the Department of Gastroenterology, Hepatology, and Immunology of Children’s Health Memorial Institute in Warsaw. It discusses the differential diagnosis of AIH and methods for assessing its stage and activity. The decision-making process regarding patients with uncomplicated AIH and those who are nonresponders to standard therapy or who develop prednisone or azathioprine complications is presented. The authors hope that this will trigger discussion on guidelines for AIH therapy and that these guidelines will be verified and accepted by all centers working with AIH patients.