Mother-to-child HBV and HCV transmission Małgorzata Pawłowska, Waldemar Halota Medical Science Review - Hepatologia 2009; 9 54-56 aaICID: 902243
Article type: Review article
IC™ Value: 3.04
Abstract provided by Publisher
Perinatal transmission of HBV accounts for the majority of chronic infections, and strategies to affect HBV burden should incorporate methods to decrease this mode of acquisition. The risk of perinatal transmission is highest in women with a high level of HBV DNA. The management of HBV during pregnancy includes recognition of maternal virologic status, assessment of liver disease, and minimization of the risk of perinatal transmission of infection. Passive and active immunoprophylaxis and monitoring for infection or immunity in new-borns is part of this management. The overall prevalence of HCV infection among pregnant women in Europe ranges from 0.2 to 3%, while the rate of mother-to-infant transmission is about 5%. Factors that increase the risk of vertical HCV transmission are high maternal HCV RNA level, HIV/HCV co-infection, maternal intravenous drug use, and delivery complications. The estimated rate of perinatal HCV infection may be reduced if infants are delivered by cesarean section prior to the rupture of membranes.