Role of cellular receptors for binding and infection of HBV and HCV Anna Parfieniuk, Anatol Panasiuk, Tadeusz Wojciech Łapiński, Robert Flisiak Medical Science Review - Hepatologia 2009; 9 57-59 aaICID: 902244
Article type: Original article
IC™ Value: 3.80
Abstract provided by Publisher
Viral replication is a multistage process. The approved antiviral therapies for chronic hepatitis B or C are based on the modulation of immune responses or inhibition of viral enzymes. Inhibition of viral entry seems to be an attractive target for the development of new antivirals. Thus the identification of cellular receptors for HBV and HCV seems to be crucial for further studies. Of the cellular proteins proposed for HBV recognition and attachment are immunoglobulin A, interleukin 6, asialoglycoprotein receptor, heparan sulfate, apolypoprote-in H, annexin V, carboxypeptidase D, and glycine decarboxylase. There are many membrane receptors proposed for the mediation of HCV entry, among them lectins (DC-SIGN, L-SIGN, ASGPr), heparan sulfate, LDL receptor, CD81, SR-B1, and claudin-1. A combination of standard therapies with new agents blocking viral entry could be beneficial for the effectiveness of treatment. However, these compounds are still in the preclinical phase of development.