Liver injury in course of cytomegalovirus infection Joanna Pawłowska, Bożena Lipka, Dorota Gliwicz, Katarzyna Dzierżanowska-Fangrat, Joanna Cielecka-Kuszyk, Bogumiła Milewska-Bobula Medical Science Review - Hepatologia 2009; 9 60-64 aaICID: 902245
Article type: Review article
IC™ Value: 3.04
Abstract provided by Publisher
Human cytomegalovirus is found throughout all geographical locations and socioeconomic groups. The infection may be acquired transplacentally or during early childhood and increases with age after infancy. Most congenitally infected infants remain asymptomatic, while a minority develops clinically apparent infection, which may include microcephaly, chorioretinitis, deafness, hepatosplenomegaly, and hyperbilirubinemia. The role of CMV in infants presenting with prolonged neonatal jaundice is unclear. Acute hepatitis develops relatively rarely and it usually occurs after blood transfusion. CMV infection in solid organ transplant recipients was associated with significant morbidity and mortality. The management of organ recipients has been revolutionized by the development of antiviral drugs. Recently used methods of preventing CMV infection may have an impact on long-term graft and patient survival.