XV Konferencja Naukowa Polskiego Towarzystwa Hepatologicznego
News
Current issue
Archival Issues
Search
Newsletter
Manuscript Submission
 » 
Journal Abstract
 
Pharmacological therapy of portal hypertension
RafaƂ Paluszkiewicz
Medical Science Review - Hepatologia 2009; 9 85-90
aaICID: 902249
Article type: Review article
IC™ Value: 3.04
Abstract provided by Publisher
 
In the last 20 years, major advances in the management of portal hypertension have resulted in a significant decrease in bleeding-related mortality. Pharmacological treatment of portal hypertension includes vasoconstrictors to decrease portal blood inflow, vasodilators to decrease hepatic resistance, and combination therapy. Oral agents, such as nonselective beta-blockers and organic nitrates, are used for long-term primary and secondary prophylaxis of variceal bleeding, while parenteral agents, such as terlipressin and somatostatin (and analogues), are used for the treatment of acute variceal bleeding. Terlipressin and somatostatin are now used usually in combination with endoscopic variceal ligation (EVL). Nonselective beta-blockers, either alone or in combination with EVL, are the recommended therapy for the prevention of first variceal bleeding and rebleeding. New drugs may target selective sites, such as carvedilol, which may reduce intrahepatic resistance without affecting the systemic circulation.

ICID 902249
 
FULL TEXT 141 KB


Related articles
  • in IndexCopernicus™
         portal hypertension [29 related records]
         variceal bleeding [3 related records]
         nonselective beta-blockers [0 related records]
         terlipressin [0 related records]
         somatostatin [90 related records]


  •  

    Copyright © Medical Science Review - Hepatologia  2017
    Page created by Index Copernicus Ltd. All Rights reserved.