Hepatotoxicity of „binge drinking” Napoleon Waszkiewicz, Sławomir Dariusz Szajda, Alina Kępka, Anna Zalewska, Beata Konarzewska, Agata Szulc, Sylwia Chojnowska, Dorota Zyta Zwierz-Gugała, Krzysztof Zwierz Medical Science Review - Hepatologia 2009; 9 106-112 aaICID: 902264
Article type: Review article
IC™ Value: 3.04
Abstract provided by Publisher
An increasing number of working young adults prefer alcohol as a recreational drug, tending to concentrate their drinking on weekends. This is called „binge drinking” and is characterized by the consumption of alcohol leading to intoxication (drinking to get drunk), often measured as having more than five drinks on one occasion. Liver injury induced by chronic alcohol consumption is well known and widely described in the literature. Less attention has been paid to bingeing-induced toxicity to the liver, even though binge drinking is more common than chronic alcoholism. This review summarizes the advances in basic and clinical research on the molecular and cellular events involved in the metabolic effects of alcohol bingeing on the liver. In the presence of comorbid conditions, such as hepatitis B or C, hemochromatosis, obesity, or acetaminophen toxicity, binge drinking can severely impact the liver. Binge drinking session can induce biochemical changes ascribed mostly to liver injury. Information given to patients on the basis of laboratory changes might enhance the current binge drinking prevention strategy.