Pathophysiological aspects of recently discovered adipokines in chronic hepatitis C Michał Kukla, Włodzimierz Mazur Medical Science Review - Hepatologia 2010; 10 18-24 aaICID: 911664
Article type: Review article
IC™ Value: 3.34
Abstract provided by Publisher
In its natural history chronic hepatitis C represents rather slowly progressive disease, but some factors associated with rapid progression were identified. Many data indicate that steatosis independently of its metabolic or viral origin, leads to liver injury and fibrosis. On the other hand there are suggestions that hepatitis C virus (HCV) may contribute to a wide spectrum of metabolic disturbances i.e.: staetosis, insulin resistance, increased prevalence of impaired glucose tolerance, type 2 diabetes mellitus and lipid metabolism abnormalities. Adipokines which are produced by adipose tissue may influence inflammatory response and insulin sensitivity and contribute to development of metabolic abnormalities in chronic hepatitis C. Recently, new adipokines – visfatin and chemerin were discovered. In this article we have summarized data pointing out a possible role of these adipokines in the pathogenesis of chronic hepatitis C.