Cell-based model of coagulation Piotr Czupryński, Marta Wawrzynowicz-Syczewska Medical Science Review - Hepatologia 2010; 10 35-39 aaICID: 911669
Article type: Review article
IC™ Value: 3.34
Abstract provided by Publisher
The coagulation model has been modified several times since its first introduction in sixties as a waterfall or a cascade coagulation concept based on the adequate level of coagulation proteins. Then it evolved through the Y-shaped scheme when the intrinsic pathway of activation, initiated by factor XII, and extrinsic pathway initiated by the complex of factor VII and tissue factor (TF) converge into a common trunk at the level of activated factors V and X (prothrombinase complex). This model, recognized as binding for many years, does not explain, however, the complexity of coagulation in vivo. It has been recently shown that intrinsic and extrinsic pathways cannot operate independently, but initiate and propagate coagulation in a complementary fashion. It is now strongly suggested that the central role in hemostasis is played by the two sets of cells: TF-bearings cells and platelets, the latter being a key element of the coagulation process. The new hemostasis concept is called a cell-based model of coagulation, which occurs in three distinct but overlapping processes: initiation, amplification and propagation.