Autoimmune reactions in patients with alcoholic liver disease Tomasz Szulżyk, Anna Parfieniuk-Kowerda, Tadeusz Wojciech Łapiński, Robert Flisiak Medical Science Review - Hepatologia 2011; 11 17-20 aaICID: 970887
Article type: Review article
IC™ Value: 3.40
Abstract provided by Publisher
4.6% of the world’s population die each year from alcohol dependence. Activation
of the immune system in the course of alcoholic liver disease plays an important role in the
pathogenesis of the disease. Understanding this mechanism could create new treatment
options, alternative to liver transplantation.
Occurring in the course of alcoholism oxidative stress stimulates the synthesis of
Malonylodialdehyd (MDA). MDA can react with deoxyguanosine and deoksyadenosine inducing
DNA mutations. Acetaldehyde and MDA stimulate synthesis in cells syngeneic protein,
against which specific antibodies are formed. Currently it is believed that the relationship of
malondialdehyde and acetaldehyde (MAA) plays a key role in the formation of syngeneic proteins
in the liver, is a stimulator of the synthesis of IL-1b, IL-6, TNF-a, MCP-1, MIP-2, adhesion
molecules ICAM, P-selectin, L-selectin, T cells and stimulates fibrosis in the liver.
